MUSCAT CHEMICAL TAG::
HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis. 1-Hydroxybenzotriazole (HOBt) plays a significant role in reducing the racemization during peptide synthesis; hence it is regularly used as a coupling additive.
N-Hydroxybenzotriazole (HOBt) has classically been used as a catalyst for peptide coupling to minimize racemization and O- to N-acyl transfer (Figure 9.6) through formation of the active ester. Unfortunately HOBt is known to react violently, especially when dry, and the shipping of HOBt is restricted
HBTU is a standard coupling agent commonly used for the activation of free carboxylic acids during the solution and solid phase peptide synthesis. 1-Hydroxybenzotriazole (HOBt) plays a significant role in reducing the racemization during peptide synthesis; hence it is regularly used as a coupling additive.
