The individual amino acid solutions show evidence of oscillatory oligomerization. In the binary solution, the behavior is controlled by the dynamics of L-Pro oligomerization. A simple model involving oligomerization, formation of catalytic oligomer aggregates and cross-catalysis provides qualitative insight into the process.
Hydroxyproline is mostly used as a diagnostic marker of bone turnover and liver fibrosis. Therapeutically, hydroxyproline is being studied as an an experimental medicine but is approved in France as a combination topical gel product called Cicactive for small, superficial wounds.
The daily turnover of collagen in humans is estimated to be 2–3 g/day,4 leading to the metabolism of 240–420 mg of hydroxyproline and the formation of 140–240 mg of glyoxylate
