N HYDROXYSUCCINIMIDE
N-Hydroxysuccinimide is an organic compound with the formula (CH₂CO)₂NOH. It is a white solid that is used as a reagent for preparing active esters in peptide synthesis. It can be synthesized by heating succinic anhydride with hydroxylamine or hydroxylamine hydrochloride.
Hygroscopic. Moisture sensitive. Incompatible with strong oxidizing agents, acid chlorides, acid anhydrides and strong bases. Store in a cool place.
Additive used in the carbodiimide method for improved amidations and peptide couplings. N-Hydroxysuccinimide can be used in the synthesis of N-hydroxysuccinimide ester via dehydration reaction in the presence of dicyclohexylcarbodiimide in carboxylic acid.
A single DEXTENZA insert releases a 0.4 mg dose of dexamethasone for up to 30 days following insertion.
