QUININE SULPHATE AR
Quinine sulfate dihydrate (QNS), IUPAC name: (8S,9R)-6-methoxy-4-quinolenyl-5-vinyl-2-quinuclidinyl methanol sulfate dihydrate, was tested as corrosion inhibitor for carbon steel in 1.5 mol L−1 HCl solution using the potentiodynamic polarization and the electrochemical impedance spectroscopy (EIS) associated with UV-Vis spectrophotometry.
Quinine sulfate at a dose of 200–300 mg at night has been used for many years to treat nocturnal leg cramps. Usually idiopathic, these muscle cramps are common, particularly in older patients. Quinine may help by decreasing the excitability of the motor end-plate and increasing the muscle refractory period.
In patients with acute uncomplicated malaria and severe chronic renal impairment, the following dosage regimen is recommended: one loading dose of 648 mg QUALAQUIN followed 12 hours later by maintenance doses of 324 mg every 12 hours.
