THIOACETAMIDE LR
Thioacetamide has been used as an organic solvent in the leather, tex- tile, and paper industries, as an accelerator in the vulcanization of buna rubber (synthetic polybutadiene), and as a stabilizer of motor fuel.
Tamarix gallica, a hepatic stimulant and tonic, was examined for its ability to inhibit thioacetamide (TAA)-induced hepatic oxidative stress, toxicity and early tumor promotion response in male Wistar rats. TAA (6.6 mmol/kg body wt. i.p) enhanced lipid peroxidation, hydrogen peroxide content, glutathione S-transferase and xanthine oxidase with reduction in the activities of hepatic antioxidant enzymes viz., glutathione peroxidase, superoxide dismutase and caused depletion in the level of hepatic glutathione content. A marked increase in liver damage markers was also observed.
