NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS
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N,N-Diisopropylethylamine may be used in the synthesis of mannosylated ovalbumin peptides. Proton scavenger used in peptide coupling, enolboration, Pd(0)-catalyzed alkoxycarbonylation of allyl phosphates and acetates, and as a catalyst in vinyl sulfone synthesis.
Key facts
- Product
- NN DIISOPROPYL EHTHYLAMINE FOR SYNTHESIS
- Part No.
- RXSOL-60-6605-027
- Category
- Lab Chemical
- Supplier
- Muscat Chemical, Barka, South Al Batinah, Oman
- Delivery
- Muscat, Sohar, Salalah, Duqm, Nizwa, Sur, Barka and Gulf ports
- Documents
- MSDS and TDS on request
- Pricing
- Quote on request — contact us or WhatsApp +968 77333599
It is commonly used as the hindered base in amide coupling reactions between a carboxylic acid (typically activated, for example, as an acid chloride, as illustrated below) and a nucleophilic amine. As DIPEA is hindered and poorly nucleophilic, it does not compete with the nucleophilic amine in the coupling reaction.
Dosage
DIPEA is a good base used for deprotonation of carboxylic acid in peptides/amino acids to give you the intermediate carboxylate. It is added based on molar ratio.