Synthesis of phthalimides. An efficient and simple method enables the N-alkylation of aromatic cyclic imides using cesium carbonate as the base in anhydrous N,N-dimethylformamide at low temperatures (20-70˚C).The method is compatible with base labile functional groups.
The Gabriel method generally doesn't work with secondary alkyl halides. Another disadvantage of this synthesis is that using acidic/basic hydrolysis gives a low yield whereas the usage of hydrazine can make the conditions of the synthesis relatively harsh.
PHTHALAMIDE FOR SYNTHESIS Supplier Oman Muscat Barka Salalah Sohar Ruwi Mutrah Nizwa Al Hamra Manah
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