Tetrahydrofuran is used as a solvent in Grignard reagent formation processes, pharmaceutical steroids and in the preparation of organometallic reagents. It is used for HPLC, spectrophotometry and environmental testing.
In the early days of HPLC, THF was commonly used as a mobile phase solvent. It has eluting strength similar to acetonitrile, but just slightly stronger. Since it technically is an ether and is very miscible with water, it is sometimes useful with reverse phase HPLC
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