Muscat chemical is one of the leading Hexamethyldisilazane HMDS distributors, manufacturers, exporters, and suppliers in Fujairah, Dubai, Sharjah, Abu Dhabi, Doha, Kuwait, Muscat Oman. We are supplied to various industrial markets including Household, Institutional Cleaning, Personal Care, and Industrial sectors including Oil fields, chemical, Animal feed additive, Food additive, Agrochemical, Fertilizer, pharmaceuticals, water treatment, Minerals, Lubricants, Marine Industry, Metal Working chemical industry, and Coatings markets.
Bis(trimethylsilyl)amine (also known as hexamethyldisilazane and HMDS) is an organosilicon compound with the molecular formula [(CH3)3Si]2NH. The molecule is a derivative of ammonia with trimethylsilyl groups in place of two hydrogen atoms. An electron diffraction study shows that silicon-nitrogen bond length (173.5 pm) and Si-N-Si bond angle (125.5°) to be similar to disilazane (in which methyl groups are replaced by hydrogen atoms) suggesting that steric factors are not a factor in regulating angles in this case.
This colorless liquid is a reagent and a precursor to bases that are popular in organic synthesis and organometallic chemistry. Additionally, HMDS is also increasingly used as a molecular precursor in chemical vapor deposition techniques to deposit silicon carbonitride thin films or coatings.
Use as reagent
Hexamethyldisilazane is employed as a reagent in many organic reactions:
1) HMDS is used as a reagent in condensation reactions of heterocyclic compounds such as in the microwave synthesis of a derivative of xanthine:
2) The HMDS mediated trimethylsilylation of alcohols, thiols, amines, and amino acids as protective groups or for intermediary organosilicon compounds is found to be very efficient and replaced TMSCl reagent.
Silylation of glutamic acid with excess hexamethyldisilazane and catalytic TMSCl in either refluxing xylene or acetonitrile followed by dilution with alcohol (methanol or ethanol) yields the derived lactam pyroglutamic acid in good yield.
3) HMDS can be used to silylate laboratory glassware and make it hydrophobic, or automobile glass, just as Rain-X does.
4) In gas chromatography, HMDS can be used to silylate OH groups of organic compounds to increase volatility, this way enabling GC-analysis of chemicals that are otherwise non-volatile.
Applications
It can be used to introduce trimethylsilyl group into organic molecules containing an active hydrogen atom such as alcohols, carboxylic acids, amines, etc. The most common industrial application is in the production of semi-synthetic beta-lactam antibiotics like ampicillin and cephalexin.
The usual procedure is to protect the carboxylic group in the antibiotic with HDMS followed by acylation with the desired acyl chloride. Finally, desilylation under mild aqueous conditions gives the desired product.
Agent for special organic synthesis. An important silylating agent (introduction of the trimethylsilyl group) manufactures medicines, such as amikacin, penicillin, and derivatives, etc.; Surface treatment agents for diatomite, silica, and titanium powder; Cohesive aid for light etching agents in the semiconductor industry.
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