Muscat chemical is one of the leading Trimethyl orthoformate distributors, manufacturers, exporters, and suppliers in Fujairah, Dubai, Sharjah, Abu Dhabi, Doha, Kuwait, Muscat Oman. We are supplied into various industrial markets including Household, Institutional Cleaning, Personal Care, and Industrial sectors including Oil fields, Agriculture, Lubricants, Marine Industry, Metal Working chemical industry, and Coatings markets.
Trimethyl orthoformate is the simplest orthoester. It is a reagent used in organic synthesis for the introduction of a protecting group for aldehydes. The product of the reaction of an aldehyde with trimethyl orthoformate is acetal. In general cases, these acetals can be deprotected back to the aldehyde by using hydrochloric acid.
The industrial synthesis of this chemical is from hydrogen cyanide and methanol.
Trimethyl orthoformate is a useful building block for creating methoxymethylene groups and heterocyclic ring systems. It introduces a formyl group to a nucleophilic substrate, e.g. RNH2 to form R-NH-CHO, which can undergo further reactions. It is used in the production of the fungicides, azoxystrobin, and picoxystrobin, as well as for some members of the floxacin family of antibacterial drugs. A number of pharmaceutical intermediates are also made from trimethyl orthoformate. Trimethyl orthoformate (TMOF) is an excellent reagent for the conversion of compatible carboxylic acids to the corresponding methyl esters.
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